The population of Orihuela exceeded the figure of 75,000 inhabitants in the year 2005. Of this total, the non-Spanish percentage is 33%: more precisely, 24,324 inhabitants are from other countries while 50,685 inhabitants are Spanish and the majority were born in the Valencia Community.

According to the data of the National Institute of Statistics, the population of Orihuela reached 75,009 inhabitants experiencing a growth of the population of more than 6,200 persons with respect to the previous year whereas in 2004 the population of Orijhuela was 68,778 inhabitants.

The United Kingdom is the European country which contributed most to the Orihuela census with 10,223 persons, while the number of those coming from Germany is 2,774.

The distribution of the non-Spanish population of Orihuela by continent is 16,200 from Europe, while 2,832 are from the American continent, another 1,492 inhabitants are from Africa and 369 come from Asia.